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Hereditary gingival fibromatosis
4 OMIM references -
1 associated gene
60 connected diseases
2 signs/symptoms
Disease Type of connection
Noonan syndrome
Distal 22q11.2 microdeletion syndrome
Chronic myeloid leukemia
Precursor B-cell acute lymphoblastic leukemia
Precursor T-cell acute lymphoblastic leukemia
Giant cell glioblastoma
Gliosarcoma
Juvenile myelomonocytic leukemia
Costello syndrome
Linear nevus sebaceus syndrome
Phakomatosis pigmentokeratotica
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia
Autosomal dominant medullary cystic kidney disease with or without hyperuricemia
LEOPARD syndrome
Metachondromatosis
Autosomal agammaglobulinemia
SHORT syndrome
Childhood-onset nemaline myopathy
Intermediate nemaline myopathy
Severe congenital nemaline myopathy
Typical nemaline myopathy
Familial papillary renal cell carcinoma
Hepatocellular carcinoma, childhood-onset
Neurofibromatosis type 2
Neurofibromatosis type 3
Autosomal recessive centronuclear myopathy
Bilateral renal agenesis
Bilateral renal dysplasia
Familial medullary thyroid carcinoma
Haddad syndrome
Hirschsprung disease
Intermittent hydrarthrosis
Multiple endocrine neoplasia type 2A
Multiple endocrine neoplasia type 2B
Noonan syndrome-like disorder with juvenile myelomonocytic leukemia
Papillary or follicular thyroid carcinoma
TRAPS syndrome
Unilateral renal dysplasia
Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis
Combined immunodeficiency due to ZAP70 deficiency
Lethal congenital contracture syndrome type 2
Megalencephaly - polymicrogyria - postaxial polydactyly - hydrocephalus
Berardinelli-Seip congenital lipodystrophy
Common variable immunodeficiency
Diffuse cutaneous systemic sclerosis
Estrogen resistance syndrome
Hartsfield-Bixler-Demyer syndrome
Heritable pulmonary arterial hypertension
Isolated trigonocephaly
Kallmann syndrome
Limited cutaneous systemic sclerosis
Myeloid neoplasm associated with FGFR1 rearrangement
Normosmic congenital hypogonadotropic hypogonadism
Oligodontia
Osteoglophonic dwarfism
Pfeiffer syndrome type 1
Pilocytic astrocytoma
Septo-optic dysplasia
Williams syndrome
Severe combined immunodeficiency due to LCK deficiency
Synonym(s):
- Autosomal dominant gingival fibromatosis
- Autosomal dominant gingival hyperplasia
- Hereditary gingival hyperplasia
Classification (Orphanet):
- Rare genetic disease
- Rare odontologic disease
Classification (ICD10):
- Diseases of the digestive system -
Epidemiological data:
Class of prevalence: unknown
Average age onset: variable
Average age of death: normal
Type of inheritance: autosomal dominant
External references:
4 OMIM references -
No MeSH references
Gene symbol UniProt reference OMIM reference
SOS1 Q07889182530
Very frequent
- Autosomal dominant inheritance
- Thickened / hypertrophic / fibromatous gingivae